first_img“We live in interesting times,” grinned David Penny in Nature,1 reporting on how estimates of evolutionary past based on comparative genomics (the molecular clock) is producing confusing results.  Apparently, evolutionary geneticists are going to have to make use of the theory of relativity – i.e., that how fast the clock ticks depends on the viewpoint of the observer.  “An analysis of genetic data sets from primates and birds provides firm evidence that molecular evolution is faster on shorter than on longer timescales,” his subtitle explained.  “The estimated times of various evolutionary events require a rethink” (emphasis added in all quotes).  It’s hard to give up a pet theory, he continued:The relative constancy of the rate at which DNA sequences evolve has been a treasured icon of molecular evolution for nearly 40 years.  The occurrence of such a stochastic ‘molecular clock’ was initially quite unexpected, and was explained by Motoo Kimura by assuming that most changes to amino-acid and nucleotide sequences were neutral – “neither beneficial nor injurious”, in Charles Darwin’s prescient phrase.    However, there have been several inklings that the rate of molecular evolution accelerates when measured over evolutionarily short timescales.  As they report in Molecular Biology and Evolution, Ho and colleagues have now put the evidence together.  Their analyses of primate and bird data sets reveal that there is indeed a decided acceleration of molecular evolution on short timescales.  This is an effect that demands explanation; moreover, estimates for the timing of recent events in population biology will need to be reconsidered.Penny discussed whether the phenomenon is real, whether it can be explained, and why it was not picked up earlier.  Part of the reason is no one was looking:For some reason, the continuum between population heterozygosity and long-term evolution has not been adequately studied.  Although it is a continuum, the techniques required may change as the timescale decreases.  For example, some concepts from long-term evolution (binary evolutionary trees with sequences studied only at the tips) have been extended into populations where trees are no longer binary, and ancestral sequences (at internal nodes) are still present in the population.  There are hints that a formal multiscale study is necessary, because even though the same underlying process is occurring, different features of trees are observed as the timescale changes.Lastly, he asked what are the consequences of this revelation.  Many time estimates will require recalculation – that’s one practical aspect.  “In some cases the constraints are from recent events, and it is the long-term events that require re-analysis,” he explained; “Much more remains to be done.”  The assumption of a single mutation rate is gone; “Even for nucleotides there are many ‘mutation rates’,” he pointed out.  Penny feels the solution is tractable, but the implication is that many former assumptions have been invalidated by the new data – hence his last sentence, “we live in interesting times.”1David Penny, “Evolutionary biology: Relativity for molecular clocks,” Nature 436, 183-184 (14 July 2005) | doi: 10.1038/436183a.Another evolutionary assumption has been overturned by more careful analysis; keep up the good work.  Next time, though, remove the assumption of evolution before making the observations.  Relativity applies to physics, not biology.  An evolutionary tale that requires relativity to keep its plot together has left the science department for the theater class (see 11/29/2004 entry).(Visited 14 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

first_imgBayern München Ancelotti defends Bayern fitness coach after Neuer injury Joe Wright Last updated 2 years ago 16:37 22/9/2017 FacebookTwitterRedditcopy Comments(0) Neuer - cropped Bongarts Bayern München Bundesliga Bayern München v Wolfsburg Wolfsburg Carlo Ancelotti The German club’s manager insists that Giovanni Mauri is not to blame for the goalkeeper’s foot problem Carlo Ancelotti says Bayern Munich fitness coach Giovanni Mauri is not to blame for Manuel Neuer’s latest foot injury.The Germany international has been forced to undergo surgery on a fractured left metatarsal and is expected to be out of action until January.Bayern 11/1 to lose 3-1 to PSG Article continues below Editors’ Picks ‘I’m getting better’ – Can Man Utd flop Fred save his Old Trafford career? Why Barcelona god Messi will never be worshipped in the same way in Argentina Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing It is the same foot Neuer broke during the Champions League quarter-final second-leg loss to Real Madrid that kept him sidelined for the final few weeks of last season.President Uli Hoeness is reportedly unhappy with Bayern’s medical staff amid suggestions they declared Neuer ready to return to action too quickly, but Ancelotti insists Mauri is not at fault.”When Manu began to play again, we thought it was the right time,” the Bayern head coach told a news conference. “It was very unfortunate, of course, because he’s now out for three months.”The only man who wasn’t involved in the game was Giovanni Mauri. That’s why it’s unfair that he gets criticism. He’s not at all responsible for Manuel’s [email protected]: “Alongside Neuer, Bernat and Alaba, Thiago will also miss out during #FCBWOB. He can train again on Sunday.” #FCBWOB— FC Bayern English (@FCBayernEN) September 21, 2017″In my opinion, Mauri is the best fitness coach in the world.”I’ve seen him [Neuer] now. The operation went well and we expect him to return in January. At the moment, he needs rest and then we’ll prepare together for the second half of the season.”Ancelotti confirmed that midfielder Thiago Alcantara will miss Friday’s Bundesliga clash with Wolfsburg, along with Neuer and long-term absentees David Alaba and Juan Bernat.Arjen Robben, however, “is in good condition and can play again”, the Italian said.”We have to remain focused and shouldn’t underestimate Wolfsburg. We’ll definitely rotate,” he added.last_img read more

first_imgCody Riley dunks so hard the rim breaks.YouTube/Marcus WilliamsFew basketball players have the raw power to destroy a basketball hoop with a dunk. Add 2017 power forward Cody Riley to that small fraternity. The 6-foot-7 five-star out of California went up for a big slam at this weekend’s 2015 Summer Block Party, and brought the rim down with him. Try not to be impressed by the raw power here—it is impossible. Riley is rated as a four star player by Scout and five stars by Rivals, 247Sports, and ESPN. His impressive list of suitors includes offers from Arizona, Arizona State, Cal, Connecticut, Kansas, Maryland, UCLA, and USC. He is also receiving interest from Duke and Kentucky.[Scout]last_img

first_imgCardale Jones swings and misses at a softball.Twitter/@STN_Sports Every year, NCAA member schools have to self-report dozens of violations, the vast majority of which are quite inane. Ohio State’s student newspaper The Lantern reports that the school reported 29 minor violations, six of which came from the football program. The most interesting of them centers on quarterback Cardale Jones’ attendance as a celebrity softball game hosted by Cleveland Browns star Joe Haden.Cardale Jones and Prime Time at Joe Haden’s Celebrity softball game— Mary Kay Cabot (@MaryKayCabot) June 6, 2015In one case, an OSU football player was told that he was neither permitted to participate in nor attend the Joe Haden Celebrity Charity Softball game in Cleveland on June 6. However, on the morning of the event he called his position coach and was told he could attend the event but not participate.Because the school had not provided written approval to attend, a violation had occurred. An OSU spokesman could not confirm the identity of the player, but redshirt junior quarterback Cardale Jones was documented to have attended the game.In response to the violation, a letter of education was provided to all football coaches and staff emphasizing the rules regarding promotional activities, as well as reviewed with football student-athletes.Braxton Miller’s Instagram photo promoting AdvoCare from the spring was also included in the report. It should be noted that there should not be an repercussions for minor offenses like these, but it is always interesting to look at the things that are deemed violations by the NCAA. Many of them are pretty ridiculous.[The Lantern via Eleven Warriors]last_img read more

first_imgYMCA releases major research today as it partners with #IAMWHOLE – an NHS anti-stigma campaign fronted by Jordan Stephens (Rizzle Kicks).Ed Sheeran: #IAMWHOLEMore than one in three young people with mental health difficulties experience stigma, according to major new research released by youth charity, YMCA.The I AM WHOLE report published today in support of an NHS anti-stigma campaign being launched by UK music star Jordan Stephens (Rizzle Kicks), also shows that, of the young people who experience this stigma, more than a third say it happens at least once a week and 54% say it originates from their own friends.Researchers spoke to more than 2,000 11 to 24-year-olds and found that 38% of those with mental health difficulties felt they were stigmatised. Of those, 56% said this stigma made them less willing to access professional support for their mental health difficulties and 70% were less likely to speak about their problems.Stigma comes in many forms for young people, including being left out of activities (54%) and verbal abuse (36%). In addition, it also damages confidence (85%) and negatively impacts on their school performance (59%).YMCA’s research supports the #IAMWHOLE campaign that is hoping to combat stigma and normalise mental health difficulties among young people. It is supported by major celebrities, including James Corden, Dermot O’Leary and Ed Sheeran and is asking people to: • Challenge harmful language used to describe mental health difficulties so that young people can ask for help without fear of negative labels. • Ask for support from friends, parents, teachers, GPs or youth workers • Show support by joining the #IAMWHOLE movement on social media and posting ‘circle on hand’ selfies in support of the anti-stigma message • Find and get help by visiting – a mental health services directory for young people created by YMCA’s Right Here project in partnership with other local groups in Jordan’s childhood home of Brighton & Hove. This site allows users to search for support, share stories about their own mental health and give feedback on services they have used for others to read. ‘Find Get Give’ also includes resources for parents and carers. Services are being added to Find Get Give all the time and providers are being encouraged to add their work using the online form.In addition, Jordan has written a new song ‘Whole’ about tackling mental health issues and the #IAMWHOLE campaign features in the song’s music video, along with young people from YMCA’s Right Here mental health project in Brighton.Denise Hatton, Chief Executive of YMCA England, the national council of YMCAs in England and Wales, said: “YMCA’s research backs up conversations we have had with young people in which they have told us mental health is one of the principle worries affecting their generation today.“What is alarming from these findings is the widespread stigma young people are now seeing or experiencing from others that is making them less likely to seek professional help. YMCA’s mental health services make a huge difference to the lives of young people with mental health difficulties but it is clear more needs to be done to support those who are currently slipping through the net.“That’s why I encourage everyone to support #IAMWHOLE to help overcome the stigma we have identified and the negative consequences young people are facing when trying to deal with their mental health difficulties alone.”Jordan Stephens, said: “The #IAMWHOLE campaign message that ‘together we are whole’ is so important and I am pleased to be launching it today on World Mental Health Day.“My mum is a trained therapist so I’ve seen how important it is for people to get the right support and not to feel isolated. I’ve also had friends and people close to me seriously affected by mental health issues. I wrote ‘Whole’ to express how I was feeling at the bottom of a situation. When the NHS suggested it could be used to give other people a way of feeling less alone, man that felt really good.”Other findings from the YMCA’s research report include: • More than three quarters (77%) of young people know someone who has experienced difficulties with their mental health. • Anxiety (66%) and depression (51%) were the most common mental health conditions experienced by young people. • Young people who believe stigma exists believe they can best tackle it by talking more about mental health (64%) and sharing their experiences (60%). • 81% of young people who believe stigma exists say that school is the best place to combat it.Dr Tim Kendall, National Clinical Director for Mental Health for NHS England, said: “A lot of work is being done by the NHS in England to support improvements in children and young people’s mental health and wellbeing, including major investment and service transformation over the next five years.“Reaching out to young people who aren’t coming forward to access services due to fear of stigma is so important and the #IAMWHOLE campaign is helping to start that conversation with young people today online, through social media and an anti-stigma challenge initiative for schools.”last_img read more

first_imgAdvertisement “We have heard from many of you about improvements needed to keep the Oscars and our Academy relevant in a changing world,” Hudson and Bailey wrote.In an effort to keep future ceremonies to three hours, the awards will be presented live and during commercial breaks. Specific categories will be determined at a later date, but the winning moments will be edited and aired in a later broadcast.The film academy is also shifting the date for the 92nd Academy Awards to earlier in the year. The 2019 ceremony will still air on Feb. 24, while the 2020 show will move to Feb. 9.The addition of a popular film category caused the most chatter Wednesday morning, as a clear effort to attract a larger audience by honouring bigger and more seen films. Bailey and Hudson said eligibility requirements will be determined at a later date. It wasn’t specified whether it would be added for the 91st Academy Awards this February.Oscar viewership is often tied to the box-office muscle of the big nominees. The 2018 best picture winner, The Shape of Water, had grossed $57.4 million in the United States by the time the awards aired and $63.9 million total. The biggest Academy Awards audience on record came in 1998, when the blockbuster Titanic was named best picture.By LINDSEY BAHR | The Associated Press Advertisement LEAVE A REPLY Cancel replyLog in to leave a comment LOS ANGELES—The Oscars are adding a new category to honour popular films and promising a brisk three-hour ceremony and a much earlier air date in 2020.John Bailey, the newly re-elected president of the Academy of Motion Picture Arts and Sciences, and film Academy CEO Dawn Hudson said in an email to members Wednesday morning that the Board of Governors met Tuesday night to approve the changes.Ratings for the 90th Academy Awards fell to an all-time low of 26.5 million viewers, down 19 per cent from the previous year and the first time the glitzy awards ceremony had fewer than 30 million viewers since 2008. Hosted by Jimmy Kimmel, the ceremony also clocked it at nearly four hours, making it the longest show in over a decade. Login/Register With: Twitter Advertisement Facebooklast_img read more

first_imgFacebook Twitter Google+LinkedInPinterestWhatsApp Facebook Twitter Google+LinkedInPinterestWhatsAppBahamas, August 4, 2017 – Nassau – Cost cutting announcements coming in now and on Thursday the Ministry of Tourism revealed that it will be cutting staff.    In a statement it was explained,  “…it is critical that we implement cost-cutting strategies within the Ministry of Tourism as in this re-organizational phase, it is imperative that costs are reduced and inefficiencies increased …  Unfortunately, a component of this plan is a workforce reduction strategy that must be executed as we strive towards creating a leaner and more streamlined and efficient organization.”During his National Address last week, Prime Minister Dr. Hubert Minnis announced that there was a freeze on public sector hiring and it was shared that a 10% across the board cut to government ministries was to be enforced.    Next Tuesday, Government begins a 23 day government employee head count across all islands.Tourism added that their cuts will mean, reassignments, dissolution of certain departments, repatriations, retirement and terminations.   The Ministry of Tourism is calling it a ‘right sizing’ exercise.#MagneticMediaNews#jobcutscomingatMinistryofTourism Related Items:#jobcutscomingatMinistryofTourism, #magneticmedianewslast_img read more