first_imgLast night, Papadosio performed to a sold-out crowd at Milwaukee’s Miramar Theatre. They played a show that had plenty of fan favorites, tight jams, and some nice sandwiches sprinkled throughout. The opener, Jaw Gems, played a good set of their own electronica to start the night.With the daylight savings time taking effect, fittingly, Papadosio opened their set with “2AM.” With acoustics out, the three-minute song sounded like it could be found on your favorite pop radio station. True to the jam band genre, surprisingly (or perhaps unsurprisingly), the song had some short, albeit sweet, improvisational moments, taking the song on a different path that rarely strays away from the norm. To begin their next tune, they had a really catchy and melodic electronica intro that went into “Hippie Babysitter.” This song has been jam vehicle for the band for a while, and this one fulfilled expectation, as it had a “Mr. Cloud’s Turtle Kingdom” sandwiched inside it.Songs from their newest release like “Oblivion” and “Each and Every Wave” followed, which were played near identical to the studio versions but still well played. “You and Yourself” continued the show and it was one of the highlights of the night. The improvisation was dark and dirty, and the whole song lasted at least fifteen minutes. Another highlight was a set-closing “We Are Water.” They made sure to end with a bang because it rivaled the “You and Yourself” for best improvisation of the night.Papadosio filled the encore slot with a sandwich of “New Love” into “The Lack of Everything” back to “New Love.” The beginning of the encore featured a particularly nice bass solo from Rob McConnell, who sounded like he could have been in a jazz club, while the latter end contained blistering energy and left the crowd wanting more. Papadosio plays tonight in Madison before heading to the South for the last dates on the Pattern Integrities spring tour. You can check out photos from last night below, courtesy of Daniel Ojeda.Setlist: Papadosio | Miramar Theatre | Milwaukee, WI | 3/11/20172AM, Hippie Babysitter > Mr. Turtle’s Cloud Kingdom > Hippie Babysitter, Oblivion, Each and Every Wave, You and Yourself, Anima Mundi, Drift, We Are WaterEncore: New Love >The Lack of Everything > New Love Load remaining imageslast_img read more

first_img CHRIS O’DOWD Lennie in Of Mice and Men Before his Broadway debut in 2014, O’Dowd was known mostly to American audiences as that funny guy in Bridesmaids and This Is 40. But after wowing us with his heartbreaking performance as Lennie in of Mice and Men and becoming the first actor in history to garner a Tony nomination for the role, we’d be thrilled to see O’Dowd return to Broadway in any show he wants. ROSE BYRNE Alice Sycamore in You Can’t Take It With You It’s safe to say the screen star’s first Broadway stint is a complete success—she garnered great reviews as Alice, a woman brings her straight-laced boyfriend home to meet her loopy family, in the new revival of You Can’t Take It With You. In a cast of Broadway heavy hitters (and scenery chewers) like James Earl Jones, Kristine Nielsen and Annaleigh Ashford, Byrne holds her own with grace, poise and humor. View Comments LENA HALL Yitzhak in Hedwig and the Angry Inch With a handful of Broadway musicals under her belt, we’d already seen Lena Hall (back when she was Celina Carvajal) shine in girly-girl roles like the shoe-obsessed Nicola in Kinky Boots. But her gender-bending turn as Hedwig’s downtrodden husband who longs to be a drag queen really piqued our interest. Her sensitive performance and rock-star vocals made her turn a winning combination—and Tony voters agreed! ADAM JACOBS Aladdin in Aladdin It’s no easy task to turn a cartoon character into a full-fledged human being, but this is exactly what Jacobs has done in Broadway’s Aladdin. His street rat doesn’t just have heart, humor and abs, but a real emotional core. Thanks to Jacobs’ earnest performance, it’s easy to cheer on Al as he tries to win over Princess Jasmine and live happily ever after—and for that, we’re proud of our boy! ANDY KARL Rocky in Rocky We never thought we’d see the day Rocky Balboa would uppercut his way to Broadway—and although the musical got knocked out far too soon, Karl’s first starring role really packed a punch. From chugging raw eggs, singing while doing pull-ups and pounding on sides of beef, Rocky was possibly the most physically demanding role of the year, proving Karl should certainly stay in the Broadway ring as a leading man. BRADLEY COOPER John Merrick in The Elephant Man Sure, this Hollywood stud already proved he was Broadway material in his 2006 debut in Three Days of Rain—he even won his first-ever trophy, a Broadway.com Audience Choice Award! But in Cooper’s longtime passion project The Elephant Man, the American Sniper and Silver Linings Playbook star delivers a tender, emotionally charged performance that can’t be missed.center_img ALYSHA UMPHRESS Hildy in On the Town After consistently wowing us in ensemble roles, this former Broadway.com video blogger made the leap to a featured role this year—and we were definitely not disappointed. Take her soulful, smooth-as-silk voice, add a dash of jazz scatting, mix them up with some spot-on comic timing, and you’ve got a star performance that’s really cooking! Broadway brought a bevy of stellar performances in 2014—theater mainstays like Audra McDonald and Kelli O’Hara delivered their usual top-notch turns like clockwork, but we’d also like to give a shout-out to 10 stars who both impressed and surprised us this year. While some are Hollywood superstars and others are complete newbies, Broadway.com is recognizing the performances of the 10 stars we absolutely can’t wait to see more from on the Main Stem…hopefully in 2015! EMILY PADGETT Daisy Hilton in Side Show Padgett and her co-star Erin Davie play conjoined twins in Side Show, and while both deserve recognition for their spectacular performances, this is Padgett’s first time opening a show. Whether she’s belting out an ’80s power ballad in Rock of Ages or singing the tender opening notes of “Who Will Love Me as I Am?” in Side Show, Padgett is one star we hope will never leave us. ALEX SHARP Christopher in The Curious Incident of the Dog in the Night-Time Sharp is the very definition of a breakout star—plucked from his senior class at Juilliard, the 25-year-old British actor’s performance is the talk of the town. While he’s a decade older than the character of Christopher Boone, a boy with Asperger syndrome who investigates the murder of his neighbor’s pooch, Sharp’s impressive physical and emotional performance is sure to get even more buzz come awards season. STEVEN PASQUALE Robert Kincaid in The Bridges of Madison County We’re so used to seeing him on our TV screens, it’s hard to believe Bridges was only Pasquale’s second time on Broadway—and his first Main Stem musical. His passionate performance as vagabond photographer Robert Kincaid made it easy to see why Francesca (played by Kelli O’Hara) would fall head over heels for him. Hey Steven, why don’t you skip pilot season in 2015 and stay with us?last_img read more

first_imgBy Dialogo April 05, 2012 At the upcoming Summit of the Americas, Paraguay will oppose the decriminalization of drugs proposed by Guatemalan President Otto Pérez Molina. “Decriminalizing drugs is very risky for the health of the population,” said the director of the National Anti-Drug Secretariat, César Damián Aquino, shortly after a meeting with the head of state, Fernando Lugo, at Government Palace. Aquino confirmed that Paraguay will not sign any document along those lines at the summit. “All the nations of South, Central, and North America are concerned about the drug-trafficking situation,” the official explained. The head of Senad said that “up to now, I don’t know in what sense liberalization is being talked about, because all the people who are talking about liberalization are people who at one time were very important in their countries, such as the former presidents of Colombia (César Gaviria), Brazil (Fernando Henrique Cardoso), and Mexico (Ernesto Zedillo).” “One group of people says ‘we should liberalize’; another group says that we can’t act to please a small group of people who might benefit, and the rest have to be dying on account of this evil,” he observed. Aquino will form part of Paraguay’s delegation that will attend the summit to be held in Cartagena (Colombia) on April 14 and 15. Study to legalize and change a paradigm.last_img read more

first_imgJacksonville lawyer saves toddler from drowning December 15, 2002 Jan Pudlow Associate Editor Regular News Jacksonville lawyer saves toddler from drowning Associate EditorA muddy dog, a spontaneous stop to window shop for new cars, and a quick-thinking lawyer converged to save a 2-year-old boy from drowning.As 36-year-old Patrick Michael Leahy, Jr., a Jacksonville lawyer specializing in maritime law, tells the story, he was pulling into his driveway, returning home from a soccer game with his two boys, ages 7 and 5.Just then, his neighbor ran over to say she was upset that her toddler son had been missing for about 10 minutes.The frantic mother said a neighborhood dog had come to play with the children in the cul-de-sac, and she had stepped into her home for just a moment to ask her husband who owned the dog.The next thing she knew, both her son and the dog were missing. And her husband was driving the car through the neighborhood on a desperate search.Leahy jogged behind the houses, looking in the wooded areas, calling the boy’s name. Without any luck, he returned to the front of his house, feeling worthless. So he jumped on his bike to continue the search.Just then, Leahy saw the dog, all wet and muddy.“It was perfect timing that I happened to go by and see the dog out of the corner of my eye. I was upset at what that may mean, so I jumped off my bike and ran to a pond, about 70 yards by 20 yards.”There in the middle of the still water of the pond, the boy floated.“What ran through my mind was ‘No!’ I sprinted into the water and swam out to get him and pulled him out to land. He was not breathing and his lips were blue.”Leahy summoned up his CPR training he had learned 15 years earlier when he was a deck officer in the U.S. Merchant Marine Academy. Though he had only practiced on mannequins and had never used the training since, he remembered how to give the boy a couple of CPR-style breaths and tried to push the water out of his lungs. He ran to the back door of the closest house and beat on the door. He ran back and turned the boy over and pushed on his back, did a couple more breaths, and sprinted to the front door of the next house, carrying the boy, where the neighbors called 911.He could tell there was water in the boy’s chest and he flipped him over, thinking gravity would help, as he gave more pushes to his lungs.“Just about then, the boy’s father was driving back by the neighborhood and saw me out front with his son. I can only imagine what was going through his mind,” Leahy recalled.“Is he breathing?” the father asked.“Not yet,” Leahy answered, pushing on the boy’s back.Finally, the boy took a breath and struggled.“We kept him turned face down to get water out of his lungs. He took struggled breaths.”In what seemed like an eternity, the ambulance arrived.The mother collapsed to the ground in tears, as a crowd of neighbors gathered.“When the ambulance pulled away, the boy was crying very hard and I told the father that’s a good sign.”Leahy, who has a daughter the same age as the boy, was very upset by the ordeal, too.As he stood in his yard soaking wet and stunned, a responding firefighter said, “I’ll give you some good PR with your kids.” The firefighter walked over to Leahy’s children and said, “You should be proud of your dad today and give him extra hugs.” With that, he turned to Leahy and gave him a wink and a pat on the shoulder before climbing into the fire truck.The next day, the little boy was fully recovered, running around, riding his tricycle.Leahy hugged his own children a little tighter, too.“The boy’s family is really very thankful and very appreciative. The mom did nothing wrong; it’s just one of those things that happens in a split second,” said Leahy, adding how easily it could have happened to his own child.Split-second timing was crucial in saving a life.How unusual, Leahy said, for him to stop and look at new cars on the way home from soccer practice.Yet, if he hadn’t that day, he would have already been inside his house when his neighbor was frantically searching for her son.His last job was in a shipping town in Norway, where he met his wife.When he relayed his rescue story to one of his friends in Norway, his friend said: “See, Mike, now you know why you ended up in Jacksonville.”“Whether you call it fate or a higher power having a hand in the thing, I have really been reflecting on being in the right place at the right time,” Leahy said.last_img read more

first_img To achieve prepandemic vaccines, researchers would have to ascertain the right dose and dose interval, determine how long priming lasts, and solve the puzzle of measuring primed immunity. Further, regulatory authorities would have to determine the trial design that could deliver those answers, the public discussion that would be necessary for prepandemic vaccines to be accepted, and the safety data that would need to be gathered once the vaccines went into use (see Bibliography: Goodman 2007). A number of the studies that have shown adjuvants may be able to stretch the vaccine supply also demonstrated a secondary benefit: The formulas protected not only against the H5N1 flu strain on which they were based, but against other H5N1 strains as well, a phenomenon called cross-reactive protection (see Bibliography: Nicholson 2001, Stephenson 2005, Govorkova 2006, Hehme 2007, Hoffenbach 2007). Most recently, the GlaxoSmithKline-backed team that described an acceptable immune response after two adjuvanted 3.8-microgram (mcg) doses found that three fourths of their subjects were protected not only against the clade 1 Vietnam virus on which the vaccine was based, but against a drifted clade 2 virus from Indonesia as well (see Bibliography: Leroux-Roels 2007). “I think priming should be done, but I am not sure how it should be done,” said Dr. John Wood, principal scientist in the division of virology at the United Kingdom’s National Institute for Biological Standards and Control. “What we don’t know is how low you can go to actually prime people. It may be that you can go much lower than where we can detect antibody. That is a regulatory headache, because you have to demonstrate that you are doing something, but there is a potential there” (see Bibliography: Wood 2007: author interview). At the moment, however, the science is thin. Much of the support for priming has come from animal studies (see Bibliography: Lipatov 2005, Govorkova 2006, Kreijtz 2007) or via computer modeling (see Bibliography: Longini 2005, Ferguson 2006, Germann 2006). A few small studies in humans have shown promising results. In one, serum from 15 volunteers who received three doses over 16 months of an adjuvanted vaccine based on a 1997 H5N3 isolate showed significant antibody response against H5N1 strains isolated years later (see Bibliography: Stephenson 2005). In another, 37 participants who had been given a baculovirus-grown, clade 3 H5 vaccine in 1998 were boosted with a single dose of the unadjuvanted 90-mcg Sanofi vaccine in 2005, and showed much higher antibody responses than participants who had not been primed but received one or two doses of the 90-mcg vaccine (see Bibliography: Treanor 2007: Immune responses). And researchers at a conference earlier this year reported that some of the participants in the phase 3 trial of the 90-mcg Sanofi vaccine were boosted with a third dose 6 months after their second dose and showed a significant rise in antibody levels that lasted for 6 months (see Bibliography: Zangwill 2007). A tough ethical problemBut the next logical step—that if vaccines can be formulated without waiting for a pandemic, they could be administered before a pandemic began—is a much tougher one to take, and policy makers are approaching it with great caution. The scientific, logistical, and especially ethical questions raised by prepandemic vaccination are grave. “Extraordinary threats call for consideration of innovative strategies that, in less-threatening circumstances, might be dismissed,” Bruce Gellin and Ben Schwartz of the Department of Health and Human Services’ National Vaccine Program Office wrote 2 years ago. “Although it has been assumed that pandemic vaccine cannot be stockpiled or that vaccination cannot occur before the start of a pandemic, might these approaches actually be possible? . . . Would receipt of a vaccine prepared before the pandemic be effective in providing some protection or in priming recipients so a single subsequent dose of vaccine would be protective?” (see Bibliography: Schwartz 2005). The danger demonstrated by both those campaigns, of causing adverse events while protecting against a disease that might never arise, has been noted in World Health Organization (WHO) policies as well. “Possible high-risk shortcuts in response to a potential emergency would be difficult to justify prior to the actual occurrence of the emergency,” the agency said after the June 2006 meeting of its Global Advisory Committee on Vaccine Safety. “Effectiveness of pandemic vaccines will not be known before the pandemic and possibly only after it is over” (see Bibliography: WHO 2006: Global Advisory Committee on Vaccine Safety, 6-7 June 2006). The prime-boost strategyThe most likely and biologically plausible use of prepandemic vaccination would be as the first half of a “prime-boost” series. People would still be given the two doses of vaccine necessary to provoke immunity in a naïve individual. But the doses would be based on different vaccine strains—the first an early best guess, the second tuned to the pandemic strain—and could be given not weeks but months or years apart if the science supported it. Yet the potential benefits of prepandemic vaccination are so alluring that governments have begun gingerly to lay groundwork for its consideration, despite the obvious difficulties of putting the idea into practice. The findings are not completely understood, though researchers agree that they make biological sense. Adjuvants stimulate the immune system in some manner that is broader than and different from the body’s reaction to the antigen packaged with them. The discovery that adjuvanted flu vaccines may invoke cross-reactivity has generated tremendous excitement—because that could allow production of at least partially protective vaccines well in advance of a pandemic’s beginning. Part 1: Flu research: a legacy of neglectPart 2: Vaccine production capacity falls far shortPart 3: H5N1 poses major immunologic challengesPart 4: The promise and problems of adjuvantsPart 5: What role for prepandemic vaccination?Part 6: Looking to novel vaccine technologiesPart 7: Time for a vaccine ‘Manhattan Project’?Bibliography Hurdles are manySo many steps separate those early results from an agreed-upon policy that would allow for prepandemic vaccines—in an annual flu shot or stockpiled until the WHO declares a pandemic imminent—that it is unrealistic to expect them to be created any time soon. The scientific questions alone are significant and novel. Any vaccination that took place before a pandemic was detected would offer uncertain amounts of both benefit and risk. The vaccine might be cross-protective against a future pandemic—but the lag time to the pandemic’s emergence might be so long that the vaccination would seem pointless. As well, the vaccine might cause a greater-than-expected rate of adverse events, causing both direct harm to recipients and indirect damage to government credibility—results that would be particularly difficult to tolerate if vaccination proved unnecessary because the pandemic did not arrive. Those risks are not theoretical: They have been demonstrated in the United States twice in recent history, in the abortive 2002 smallpox vaccination campaign and the 1976 swine-flu campaign (see Bibliography: Kotalik 2005), which has haunted US flu decision-making ever since. Editor’s note: This is the fifth in a seven-part series investigating the prospects for development of vaccines to head off the threat of an influenza pandemic posed by the H5N1 avian influenza virus. The series puts promising advances in vaccine technology in perspective by illuminating the formidable barriers to producing large amounts of an effective and widely usable vaccine in a short time frame. Part 4 examined the possibility of using adjuvants to stretch the supply of pandemic vaccines and the regulatory barriers to that strategy. Recognizing those hurdles, the European Centre for Disease Prevention and Control said in August that while it welcomes the development of prepandemic vaccines, it would not support administering them until a WHO declaration of pandemic phase 5 or 6, meaning significant human-to-human transmission is occurring or a pandemic is under way (see Bibliography: ECDC 2007: “Pre-pandemic” vaccines might offer protection but uncertainties remain). The pandemic vaccine puzzle Oct 31, 2007 (CIDRAP News) – Experiments with vaccine adjuvants have raised some hope of removing one of the great stumbling blocks to pandemic influenza preparedness: the impossibility of making a vaccine that protects against a pandemic virus before that virus actually emerges. last_img read more

first_imgGerman shipbuilder Meyer Werft held a steel cutting ceremony for Saga Cruises’ first new cruise ship, the Spirit of Discovery, on February 28.With the event, the shipbuilder started the construction of the first sections and blocks for the new vessel at its Building Dock I in Papenburg.The UK-based cruise line informed that the Spirit of Discovery is scheduled to take to the oceans in just 18 month’s time when it joins the company in summer 2019.With a capacity to accommodate 999 passengers, the Spirit of Discovery is the first of two vessels which were ordered by Saga Cruises in January 2016 and September 2017, respectively.The second cruise ship, the Spirit of Adventure, is scheduled to be delivered in summer 2020.The ships each have an overall length of 236 metres, a width of 31.2 metres and a tonnage measurement of 58,250 GT.last_img read more

first_imgThe Indiana Department of Transportation (INDOT) will suspend most highway construction and maintenance activities on Friday, Aug. 30 ahead of the Labor Day holiday weekend. INDOT has a policy of limiting restrictions during highly traveled times in order to optimize mobility and public safety.INDOT and contractor workers will stop work in most construction zones and, where possible, restrictions will be removed. Some closures and restrictions will remain on projects that cannot safely reopen to traffic.Motorists traveling on Labor Day through Indianapolis via I-65 or I-70 will encounter restricted travel lanes and highway work zones near the north and south splits as contractors modify pavement markings, uncover signs and place barricades and barrier wall ahead of the midnight closure. I-465 around the south side of Indianapolis is the official detour for the downtown I-65/I-70 closure.Motorists traveling this weekend should also be alert for drivers who might be under the influence of alcohol. Recent data from the Indiana Criminal Justice Institute show alcohol-impaired driving fatalities rose nearly 13 percent in 2012. INDOT encourages all motorists to avoid drinking and driving, and to report suspicious or reckless driving behaviors to law enforcement.last_img read more

first_imgRelatedPosts No directive to constitute disciplinary committee against us — Ojudu, others ‘Army Officer’ in EFCC net for alleged multiple fraud COVID-19: NCAA to revoke erring airlines licence over non-compliance Bresica have parted company with head coach Eugenio Corini for the second time this season. The Serie A club announced the news on Wednesday, with reports claiming that Diego Lopez is set to take over. Corini was previously sacked in November before he was re-hired one month later, replacing Italian World Cup winner Fabio Grosso. A club statement read: “Brescia Calcio announce to have relieved Eugenio Corini of the position as coach for the first team. “The club wants to thank Mr. Corini and his staff for the professionalism, dedication and commitment they have shown.” Brescia, who were promoted from Serie B last season, are currently 19th in the table, four points from safety. And reports emerging from Italy suggest club president Massimo Cellino has already agreed terms with former Cagliari and Bologna manager Lopez to take over the first-team.last_img read more